Ethanol → HCID 10271572, 화합물

HRID 2183618노트

반응식

HRID 2183618 반응식
[Br:1][CH:2]([CH3:15])[C:3]([C:5]1[S:9][C:8]2[CH:10]=[CH:11][CH:12]=[C:13]([Cl:14])[C:7]=2[CH:6]=1)=O.[NH:16]1[CH2:20][CH2:19][NH:18][C:17]1=[S:21].C(O)C>C(O)(=O)C>[BrH:1].[Cl:14][C:13]1[C:7]2[CH:6]=[C:5]([C:3]3[N:18]4[CH2:19][CH2:20][N:16]=[C:17]4[S:21][C:2]=3[CH3:15])[S:9][C:8]=2[CH:10]=[CH:11][CH:12]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 2723650EthylenethioureaHCID 22474281HCID 22474281, 화합물

생성물 1

HCID 10271572HCID 10271572, 화합물수율 69.3%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 2-bromo-1-(4-chlorobenzo[b]thiophen-2-yl)propan-1-one (0.74 g), 2-imidazolidinethione (0.19 g) and ethanol (15 ml) was heated under reflux for 20 minutes. Acetic acid (7 ml) was added and the mixture was heated under reflux for 17 hours then cooled in ice-water. The resulting solid was collected by filtration and dried in vacuo at 60° C. to give 3-(4-chlorobenzo[b]thiophen-2-yl)-2-methyl-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide (0.5 g) as a white solid, m.p. 246-248° C.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 20 minutes
  3. temperaturethe mixture was heated
  4. temperatureunder reflux for 17 hours
  5. filtrationThe resulting solid was collected by filtration
  6. customdried in vacuo at 60° C.

출처 및 근거

ORD 기록
ord-5c91468c27784922870b1a87825cd347
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06900216B2

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