Sodium Carbonate → HCID 9943990, 화합물

HRID 2183633노트

반응식

HRID 2183633 반응식
C(=O)([O-])[O-].[Na+].[Na+].Br.[S:8]1[C:12]([C:13]2[N:14]3[CH2:20][CH2:19][N:18]=[C:15]3[S:16][CH:17]=2)=[CH:11][C:10]2[CH:21]=[CH:22][CH:23]=[CH:24][C:9]1=2>ClCCl.O>[S:8]1[C:12]([C:13]2[N:14]3[CH2:20][CH2:19][N:18]=[C:15]3[S:16][CH:17]=2)=[CH:11][C:10]2[CH:21]=[CH:22][CH:23]=[CH:24][C:9]1=2

참가 물질

5

반응물 2

HCID 10340Sodium CarbonateHCID 22474170HCID 22474170, 화합물

생성물 1

HCID 9943990HCID 9943990, 화합물수율 90.5%

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매

실험 절차

Sodium carbonate (9.29 g) was added at 0° C. to a stirred suspension of 3-(benzo[b]thiophen-2-yl)-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide (19.0 g) in a mixture of dichloromethane (300 ml) and water (300 ml). The mixture was stirred at ambient temperature for 3 hours, then the organic phase was separated, washed with water (200 ml) and saturated aqueous sodium chloride solution (200 ml), dried (Na2SO4) and the solvents were removed in vacuo to give 3-(benzo[b]thiophen-2-yl)-5,6-dihydroimidazo[2,1-b]thiazole as a brown solid (13.1 g) which was used without further purification.

후처리

  1. customthe organic phase was separated
  2. washwashed with water (200 ml) and saturated aqueous sodium chloride solution (200 ml)
  3. dry with materialdried (Na2SO4)
  4. customthe solvents were removed in vacuo

출처 및 근거

ORD 기록
ord-6862eca620ff44419eb52980ee99c1a7
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06900216B2

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