Ethanol → 3-(4-Chlorobenzo[b]thiophen-2-yl)-2-ethyl-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide

HRID 2183645노트

반응식

HRID 2183645 반응식
[Br:1][CH:2]([CH2:15][CH3:16])[C:3]([C:5]1[S:9][C:8]2[CH:10]=[CH:11][CH:12]=[C:13]([Cl:14])[C:7]=2[CH:6]=1)=O.[NH:17]1[CH2:21][CH2:20][NH:19][C:18]1=[S:22].C(O)C>C(O)(=O)C>[BrH:1].[Cl:14][C:13]1[C:7]2[CH:6]=[C:5]([C:3]3[N:19]4[CH2:20][CH2:21][N:17]=[C:18]4[S:22][C:2]=3[CH2:15][CH3:16])[S:9][C:8]=2[CH:10]=[CH:11][CH:12]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 2723650EthylenethioureaHCID 224739972-Bromo-1-(4-chlorobenzo[b]thiophen-2-yl)butan-1-one

생성물 1

HCID 224738223-(4-Chlorobenzo[b]thiophen-2-yl)-2-ethyl-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide수율 71.8%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 2-bromo-1-(4-chlorobenzo[b]thiophen-2-yl)butan-1-one (1.06 g), 2-imidazolidinethione (0.255 g) and ethanol (25 ml) was heated under reflux for 20 minutes. Acetic acid (12 ml) was added, the mixture was heated under reflux for 21 hours, then the solvents were removed in vacuo and the solid residue recrystallised from propan-2-ol (40 ml) to give 3-(4-chlorobenzo[b]thiophen-2-yl)-2-ethyl-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide (0.72 g) as a white solid, m.p. 187-189° C.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 20 minutes
  3. temperaturethe mixture was heated
  4. temperatureunder reflux for 21 hours
  5. customthe solvents were removed in vacuo
  6. customthe solid residue recrystallised from propan-2-ol (40 ml)

출처 및 근거

ORD 기록
ord-67c19d293d4f43d8bafa21e1ac13f0dd
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06900216B2

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