Methanol → 1-Piperidinecarboxylic acid, 3-[(R)-(3-chlorophenyl)hydroxymethyl]-, 1,1-dimethylethyl ester, (3R)-

온도

-15 °C

To a solution of (R)-tert-butyl 3-(3-chlorobenzoyl)piperidine-1-carboxylate (178 g, 0.55 mol) in anhydrous THF (600 mL) at −15° C. under nitrogen was added dropwise a solution of 1 M R-CBS-oxazaborolidine in toluene (82 mL, 82 mmol, 0.15 eq). After stirring for 1 hr at −15° C., a solution of 10 M BH3 in THF (60 mL, 0.60 mol, 1.1 eq) was added dropwise. After addition, the reaction mixture was stirred for 2 hr at −15° C. Methanol (400 mL) was added dropwise carefully at −15° C. The solvent was removed under reduced pressure, the residue was purified by column chromatography on silica gel eluting with AcOEt/hexane (1:30→1:15) to provide the light yellow oil (95 g, HPLC purity≧70%, isomer ratio≧3:1). The mixture was dissolved in EtOAc till the alcohol was just dissolved (about 5 mL/1 g), the solvent was removed on the rotary evaporator until a few crystals appeared. The solution was cooled to rt slowly and stood for 1-2 hr. To the above solution was added hexane (about 300 mL) and then filtered, the crystals were washed with cool hexane and re-crystallized from AcOEt-hexane twice to afford the pure isomer (R)-tert-butyl 3-((R)-(3-chlorophenyl)(hydroxy)methyl)piperidine-1-carboxylate (20 g, ee≧99%).

1. additionAfter addition
2. stirringthe reaction mixture was stirred for 2 hr at −15° C
3. customThe solvent was removed under reduced pressure
4. customthe residue was purified by column chromatography on silica gel eluting with AcOEt/hexane (1:30→1:15)
5. customto provide the light yellow oil (95 g, HPLC purity≧70%, isomer ratio≧3:1)
6. dissolutionwas just dissolved (about 5 mL/1 g)
7. customthe solvent was removed on the rotary evaporator until a few crystals
8. temperatureThe solution was cooled to rt slowly
9. waitstood for 1-2 hr
10. additionTo the above solution was added hexane (about 300 mL)
11. filtrationfiltered
12. washthe crystals were washed with cool hexane
13. customre-crystallized from AcOEt-hexane twice

ORD 기록

ord-94910d8465ad46dd8bec26ab0ceee2b5

출처 데이터셋

uspto-grants-2012_06

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08198453B2