Morpholine → 1-Morpholin-4-yl-[2,6]naphthyridine

HRID 2183722노트

반응식

HRID 2183722 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][N:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>>[N:12]1([C:2]2[C:11]3[C:6](=[CH:7][N:8]=[CH:9][CH:10]=3)[CH:5]=[CH:4][N:3]=2)[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

참가 물질

3

반응물 2

HCID 8083MorpholineHCID 128847741-Chloro-2,6-naphthyridine

생성물 1

HCID 219836751-Morpholin-4-yl-[2,6]naphthyridine

실험 절차

To 1-chloro-2,6-naphthyridine (164.3 mg, 0.998 mmol) (prepared as described in Van den Haak et al, J. Org. Chem 1982, 47 (9), 1673-7) was added morpholine (15 mL) and the mixture was heated at reflux for 4 h. Removal of the volatile components gave 216.6 mg of 1-morpholin-4-yl-[2,6]naphthyridine as a beige solid.

후처리

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 4 h
  3. customRemoval of the volatile components

출처 및 근거

ORD 기록
ord-6a51cee6e9ef4a6381f487ba5e125aef
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06900220B2

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