Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Chloro-4-(chloromethyl)benzene → 4-Chlorobenzyl N-methyl-N-phenylglycinate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Chloro-4-(chloromethyl)benzene | HCID 7723 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | N-Methyl-N-phenyl-glycine | HCID 420843 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 4-Chlorobenzyl N-methyl-N-phenylglycinate | HCID 22475619 | 68% |
반응 단계
The product from step 2 (220 mg, 1.3 mmol) was dissolved in DMF (7 mL) and Cs2CO3 (652 mg, 2.0 mmol) added, followed by 4-chlorobenzyl chloride (214 mg, 1.3 mmol). Allow reaction mixture to stir at ambient temperature over 18 hours. The reaction mixture was diluted with EtOAc and washed several times with brine. The organic layer was dried (Na2SO4), filtered and concentrated to afford the title compound as a yellow oil (68%). MS (ES+) m/z 290 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06900244B2 |
| 출처 데이터셋 | uspto-grants-2005_05 |
| ORD ID | ord-438b7ff164b94e54ab70879eeafb9775 |
| 출처 메모 | uspto-grants-2005_05 |