Potassium Carbonate → 1-[(4-Ethynylphenoxy)methyl]-3-fluorobenzene

HRID 2184353노트

반응식

HRID 2184353 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][CH:21]=1)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]#[C:14][Si](C)(C)C)=[CH:9][CH:8]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[F:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][CH:21]=1)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]#[CH:14])=[CH:9][CH:8]=1

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 22476627({4-[(3-Fluorophenyl)methoxy]phenyl}ethynyl)(trimethyl)silane

생성물 1

HCID 224766251-[(4-Ethynylphenoxy)methyl]-3-fluorobenzene

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 2.06 g (6.9 mmol) of [4-(3-fluoro-benzyloxy)-phenylethynyl]-trimethyl-silane in 35 ml methanol is treated with 95 mg (0.69 mmol) of solid potassium carbonate. The mixture is stirred at RT for 3 h, concentrated and treated with saturated aqueous sodium hydrogencarbonate. The compound is extracted three times with dichloromethane, dried over magnesium sulfate and concentrated to yield 1.53 g (98%) of a slightly brown oil. MS (neg.ions): m/e=225.4 (M−H).

후처리

  1. concentrationconcentrated
  2. additiontreated with saturated aqueous sodium hydrogencarbonate
  3. extractionThe compound is extracted three times with dichloromethane
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated
  6. customto yield 1.53 g (98%) of a slightly brown oil

출처 및 근거

ORD 기록
ord-bc4eb899c74b4bd2ab2f8e5febe080d8
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06900354B2

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