Nitric Acid → 4-Mesyl-2-nitrotoluene

HRID 21844

반응식

HRID 21844 반응식
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[N+:12]([O-])([OH:14])=[O:13]>S(=O)(=O)(O)O>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[C:7]([N+:12]([O-:14])=[O:13])[CH:6]=1)(=[O:3])=[O:4]

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 18521p-Tolyl methyl sulfone

생성물 1

HCID 6871254-Mesyl-2-nitrotoluene

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매2회

반응 조건

온도
10 °C

실험 절차

68 g of 4-methylsulfonyltoluene in 400 ml of concentrated sulfuric acid were admixed at 0°-10° C. with a mixture of 80 ml of concentrated sulfuric acid and 31 ml of 65% strength by weight nitric acid. The reaction mixture was stirred at 10° C. for 2 hours and at room temperature for a further 2 hours. It was then poured onto about 1 kg of ice, and the solids were filtered off with suction, washed with water and dried at 50° C. under reduced pressure, to leave 85 g of 4-methylsulfonyl-2-nitrotoluene (melting point 112°-115° C.).

후처리

  1. filtrationthe solids were filtered off with suction
  2. washwashed with water
  3. customdried at 50° C. under reduced pressure

출처 및 근거

ORD 기록
ord-6b452798bf2a4573bf046125764f2e48
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05424481

연결된 노트

불러오는 중…