참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methyl cyanoacetate | HCID 7747 | — |
| 반응물 | o-Methylvalerolactim | HCID 138567 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Cyano-2-piperidinylidene-ethanoic acid methyl ester | HCID 69042496 | 80% |
반응 단계
A mixture of 2,3,4,5-tetrahydro-6-methoxypyridine (1.1 g, 9.72 mmol) and cyanoacetic acid methyl ester (1 g, 10.1 mmol) in 40 mL THF was heated at 70° C. overnight. The reaction was cooled, and solvent was removed in vacuo. The resulting residue was purified on flash column to afford cyano-2-piperidinylidene-ethanoic acid methyl ester (1.4 g, 80%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08198456B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_06 |
|---|
| ORD ID | ord-0b3505796c35498b9aa8c9bd385cf3ef |
|---|
| 출처 메모 | uspto-grants-2012_06 |
|---|
