Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrazine → 1H-Pyrazolo(4,3-b)pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrazine | HCID 9321 | — |
| 반응물 | 3-Fluoro-2-pyridinecarboxaldehyde | HCID 11344017 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 1H-Pyrazolo(4,3-b)pyridine | HCID 21643653 | 60.4% |
반응 단계
A mixture of 3-fluoro-2-pyridinecarboxaldehyde (4 g, 32 mmol) and hydrazine (20.5 g) was kept at 115° C. for 7 hr, then cooled to rt. The reaction mixture was diluted with water and extracted with EtOAc. The organic phases were combined, washed with brine, and dried. Concentration followed by flash chromatography afforded 1H-pyrazolo[4,3-b]pyridine (2.3 g, 60.4%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08198456B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-2a2bc17e86064d979af9365c6fef2b04 |
| 출처 메모 | uspto-grants-2012_06 |