Hydrazine → 1H-Pyrazolo(4,3-b)pyridine

HRID 218464

반응식

HRID 218464 반응식
F[C:2]1[C:3]([CH:8]=O)=[N:4][CH:5]=[CH:6][CH:7]=1.[NH2:10][NH2:11]>O>[NH:10]1[C:2]2[C:3](=[N:4][CH:5]=[CH:6][CH:7]=2)[CH:8]=[N:11]1

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 113440173-Fluoro-2-pyridinecarboxaldehyde

생성물 1

HCID 216436531H-Pyrazolo(4,3-b)pyridine수율 60.4%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 3-fluoro-2-pyridinecarboxaldehyde (4 g, 32 mmol) and hydrazine (20.5 g) was kept at 115° C. for 7 hr, then cooled to rt. The reaction mixture was diluted with water and extracted with EtOAc. The organic phases were combined, washed with brine, and dried. Concentration followed by flash chromatography afforded 1H-pyrazolo[4,3-b]pyridine (2.3 g, 60.4%).

후처리

  1. extractionextracted with EtOAc
  2. washwashed with brine
  3. customdried
  4. concentrationConcentration

출처 및 근거

ORD 기록
ord-2a2bc17e86064d979af9365c6fef2b04
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08198456B2

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