Methanol → Benzenebutanoic acid, 2-hydroxy-, methyl ester

HRID 2184640노트

반응식

HRID 2184640 반응식
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12].S(=O)(=O)(O)O.[CH3:19]O>>[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][CH2:10][C:11]([O:13][CH3:19])=[O:12]

참가 물질

4

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 41894984-(2-hydroxyphenyl)butanoic Acid

생성물 1

HCID 12079672Benzenebutanoic acid, 2-hydroxy-, methyl ester

실험 절차

4-(2-Hydroxyphenyl)butyric acid (1 g, 5.55 mmol) was dissolved in 20 mL anhydrous methanol, and 5 mL sulfuric acid. The mixture was heated to reflux for 6 hours. After aqueous workup, 1.14 g of methyl 4-(2-hydroxyphenyl)butyrate was obtained. 1H NMR (CDCl3): 1.92 (q, 2H), 2.40 (t, 2H), 2.65 (t, 2H), 3.72 (s, 3H), 6.84 (m, 2H), 7.10 (m, 2H).

후처리

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 6 hours

출처 및 근거

ORD 기록
ord-24f623900a994a6b983387ef760d3d2d
출처 데이터셋
uspto-grants-2002_06
특허 번호
US06399534B2

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