Isocyanate → Methyl 3-{[(N-Methylcarbamoyl)methylthio]methyl}-4-oxo-4-(3-pyridyl)butanoate

HRID 2184729노트

반응식

HRID 2184729 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]([C:9](=[CH2:15])[CH2:10][C:11]([O:13][CH3:14])=[O:12])=[O:8])[CH:2]=1.[CH3:16][NH:17][C:18](=[O:21])[CH2:19][SH:20].[N-]=C=O>ClCCl.C(N(CC)CC)C>[CH3:16][NH:17][C:18]([CH2:19][S:20][CH2:15][CH:9]([C:7](=[O:8])[C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1)[CH2:10][C:11]([O:13][CH3:14])=[O:12])=[O:21]

참가 물질

6

반응물 3

HCID 105034IsocyanateHCID 4047279Acetamide, 2-mercapto-N-methyl-HCID 22457736Methyl 3-(3-Pyridylcarbonyl)but-3-enoate

생성물 1

HCID 22457729Methyl 3-{[(N-Methylcarbamoyl)methylthio]methyl}-4-oxo-4-(3-pyridyl)butanoate

시약·촉매·용매 2

HCID 6344Dichloromethane용매2회HCID 8471Triethylamine용매

실험 절차

A solution of methyl 3-(3-pyridylcarbonyl)but-3-enoate in dichloromethane (0.5 mL, 0.1 mM), triethylamine in dichloromethane (0.5 mL, 0.1 mM) and N-methyl-2-sulfanylacetamide (0.6 mL, 0.12 mmol) was stirred for 24 h. PS isocyanate resin (60 mg) was added to the reaction mixture and stirred for 24 h. The solution was filtered and concentrated to give the title compound in quantitative yield, ESMS, (M+1)+311.

후처리

  1. filtrationThe solution was filtered
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-97fe9f0aa32c4e15b247125eab8ce31c
출처 데이터셋
uspto-grants-2002_06
특허 번호
US06399606B1

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