Nitric Acid → 3-nitro-9-isopropyl-9H-carbazole

HRID 2184930노트

반응식

HRID 2184930 반응식
[CH:1]([N:4]1[C:16]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[C:10]2[C:5]1=[CH:6][CH:7]=[CH:8][CH:9]=2)([CH3:3])[CH3:2].[N+:17]([O-])([OH:19])=[O:18].O>CC(O)=O>[CH:1]([N:4]1[C:16]2[CH:15]=[CH:14][C:13]([N+:17]([O-:19])=[O:18])=[CH:12][C:11]=2[C:10]2[C:5]1=[CH:6][CH:7]=[CH:8][CH:9]=2)([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 944Nitric AcidHCID 962WaterHCID 738739H-Carbazole, 9-(1-methylethyl)-

생성물 1

HCID 6174713-nitro-9-isopropyl-9H-carbazole수율 87%

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

실험 절차

A solution of 9-Isopropyl-9H-carbazole (Acros, 1.5 9, 7.2 mmol) in AcOH (50 ml) was treated dropwise with a solution of nitric acid (3.35 ml) in AcOH (10 mL) over 30 minutes. When the reaction was complete the mixture was poured into water and stirred for 15 minutes, then the solid filtered and washed with Et2O to afford the desired product as a solid (1.6 g, 87%).

후처리

  1. filtrationthe solid filtered
  2. washwashed with Et2O

출처 및 근거

ORD 기록
ord-fc95bb89ea3c446d8d28849dd4eddc91
출처 데이터셋
uspto-grants-2002_06
특허 번호
US06399631B1

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