Carbon Dioxide → HCID 22459178, 화합물

HRID 2184989노트

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HRID 2184989 반응식
[CH3:1][O:2][C:3]1[C:16]2[O:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[CH2:8][C:7]=2[CH:6]=[CH:5][CH:4]=1.C([N-]C(C)C)(C)C.[Li+].C(=O)=O.COC1C2OC3C(=CC=CC=3)C(C(O)=O)C=2C=CC=1.C(Cl)(=O)[C:48]([Cl:50])=[O:49]>O1CCCC1.C1(C)C=CC=CC=1.CN(C=O)C>[CH3:1][O:2][C:3]1[C:16]2[O:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[CH:8]([C:48]([Cl:50])=[O:49])[C:7]=2[CH:6]=[CH:5][CH:4]=1

참가 물질

8

반응물 5

HCID 280Carbon DioxideHCID 65578Oxalyl chlorideHCID 2724682Lithium diisopropylamideHCID 125543394-Methoxy-9H-xantheneHCID 22459180HCID 22459180, 화합물

생성물 1

HCID 22459178HCID 22459178, 화합물

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 21735183Dimethylformamide toluene용매

실험 절차

(RS)-4-Methoxy-9H-xanthene-9-carbonyl chloride was prepared according to general methods described in WO 9706178. 4-Methoxy-xanthene [J.Med.Chem., 32(10), 2357(1989)] was deprotonated with lithium diisopropylamide in tetrahydrofuran followed by treatment with carbon dioxide. The resulting (RS)-4-methoxy-9H-xanthene-9-carboxylic acid (white solid and MS: m/e=256.0 (M+)) was chlorinated with oxalyl chloride in toluene/DMF and yielded after evaporation of the reagent and solvents, the crude acid chloride, which was directly used without further purification.

후처리

  1. customyielded
  2. customafter evaporation of the reagent and solvents
  3. customthe crude acid chloride, which was directly used without further purification

출처 및 근거

ORD 기록
ord-cf85ecd894d449fa84316210d753f08b
출처 데이터셋
uspto-grants-2002_06
특허 번호
US06399641B1

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