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N-[3-[2-(diisopropylamino)ethoxy]-4-methoxypheny]-4-iodobenzamide → N-[3-[2-[Bis(1-methylethyl)amino]ethoxy]-4-methoxyphenyl]-4-(2-thienyl)benzamide

HRID 2185021
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HRID 2185021 반응식
[Br-].[S:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[Zn+].[CH:8]([N:11]([CH:33]([CH3:35])[CH3:34])[CH2:12][CH2:13][O:14][C:15]1[CH:16]=[C:17]([NH:23][C:24](=[O:32])[C:25]2[CH:30]=[CH:29][C:28](I)=[CH:27][CH:26]=2)[CH:18]=[CH:19][C:20]=1[O:21][CH3:22])([CH3:10])[CH3:9]>O1CCCC1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH3:35][CH:33]([N:11]([CH:8]([CH3:10])[CH3:9])[CH2:12][CH2:13][O:14][C:15]1[CH:16]=[C:17]([NH:23][C:24](=[O:32])[C:25]2[CH:26]=[CH:27][C:28]([C:3]3[S:2][CH:6]=[CH:5][CH:4]=3)=[CH:29][CH:30]=2)[CH:18]=[CH:19][C:20]=1[O:21][CH3:22])[CH3:34]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 18672563N-[3-[2-(diisopropylamino)ethoxy]-4-methoxypheny]-4-iodobenzamideHCID 178419761HCID 178419761, 화합물

생성물 1

HCID 22459309N-[3-[2-[Bis(1-methylethyl)amino]ethoxy]-4-methoxyphenyl]-4-(2-thienyl)benzamide

시약·촉매·용매 2

HCID 178418397HCID 178418397, 화합물촉매HCID 8028Tetrahydrofuran
용매
2회

실험 절차

A solution of 2-thienylzinc bromide in tetrahydrofuran (0.5M, 5 mL, 2.5 mmol) was added to a solution of N-[3-[2-(diisopropylamino)ethoxy]-4-methoxypheny]-4-iodobenzamide (WO 99/01127) (0.5 g, 1 mmol) in tetrahydrofuran (5 mL) containing tetrakis(triphenylphosphine)palladium(0) (80 mg, 0.06 mmol), and the mixture was stirred at RT for 16 h. The reaction was quenched with saturated ammonium chloride and extracted with ether and dichloromethane. The organic phase was dried (MgSO4), concentrated in vacuo, and chromatographed (silica gel, 5% methanol/dichloromethane) to afford the title compound (0.1 g) MS(ES) m/e 452.8 [M+H]+.

후처리

  1. customThe reaction was quenched with saturated ammonium chloride
  2. extractionextracted with ether and dichloromethane
  3. dry with materialThe organic phase was dried (MgSO4)
  4. concentrationconcentrated in vacuo
  5. customchromatographed (silica gel, 5% methanol/dichloromethane)

출처 및 근거

ORD 기록
ord-29b6ff22035b4f50999b27152e1870bd
출처 데이터셋
uspto-grants-2002_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06399656B1

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