3-Methoxyphenol → 1-(3-Methoxyphenoxy)-4,4-dimethyl-2-pentanone

HRID 2185055노트

반응식

HRID 2185055 반응식
Br[CH2:2][C:3](=[O:9])[CH2:4][C:5]([CH3:8])([CH3:7])[CH3:6].[CH3:10][O:11][C:12]1[CH:13]=[C:14]([OH:18])[CH:15]=[CH:16][CH:17]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C=O)C>[CH3:10][O:11][C:12]1[CH:13]=[C:14]([CH:15]=[CH:16][CH:17]=1)[O:18][CH2:2][C:3](=[O:9])[CH2:4][C:5]([CH3:8])([CH3:7])[CH3:6]

참가 물질

5

반응물 3

HCID 90073-MethoxyphenolHCID 10796Cesium carbonateHCID 2225851-Bromo-4,4-dimethylpentan-2-one

생성물 1

HCID 224590191-(3-Methoxyphenoxy)-4,4-dimethyl-2-pentanone

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A stirred solution of the product from Step B (1.626 grams) in dry DMF (18 mL) was combined with 3-methoxyphenol (1.256 grams) and cesium carbonate (3.292 grams). The mixture was stirred for 2.5 hours. The reaction was partitioned between isopropyl acetate and pH4 pthalate buffer. The organic was washed twice with water, dried over magnesium sulfate and filtered. Concentration furnished an oil from which the title compound was isolated by chromatography over silica gel (4:1 hex/ethyl acetate).

후처리

  1. customThe reaction was partitioned between isopropyl acetate and pH4
  2. washThe organic was washed twice with water
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationConcentration

출처 및 근거

ORD 기록
ord-353fa67eaf91444884bdc6f3ff8ec5ae
출처 데이터셋
uspto-grants-2002_06
특허 번호
US06399640B1

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