1-(2-Ethoxy-4-nitrophenyl)piperidin-2-one → HCID 59586675, 화합물
반응식
[CH2:1]([O:3][C:4]1[CH:9]=[C:8]([N+:10]([O-])=O)[CH:7]=[CH:6][C:5]=1[N:13]1[CH2:18][CH2:17][CH2:16][CH2:15][C:14]1=[O:19])[CH3:2].[H][H]>C1COCC1.[Pd]>[NH2:10][C:8]1[CH:7]=[CH:6][C:5]([N:13]2[CH2:18][CH2:17][CH2:16][CH2:15][C:14]2=[O:19])=[C:4]([O:3][CH2:1][CH3:2])[CH:9]=1참가 물질
5
실험 절차
235 mg (0.889 mmol) of the product from example 90A are dissolved in 40 ml of THF and admixed with 50 mg of 10% palladium on activated carbon. Hydrogenation is effected in a hydrogen atmosphere under standard pressure overnight, then the mixture is filtered with suction through kieselguhr, washed three times with THF and concentrated cautiously under reduced pressure. This affords 262 mg of crude product, which is converted further without purification.
후처리
- filtrationthe mixture is filtered with suction through kieselguhr
- washwashed three times with THF
- concentrationconcentrated cautiously under reduced pressure
- customThis affords 262 mg of crude product, which is converted further without purification
출처 및 근거
- ORD 기록
- ord-47053602dd5a418fa447d7183d4fb3fd
- 출처 데이터셋
- uspto-grants-2012_06
- 특허 번호
- US08198267B2
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