Trifluoroacetic acid → 4-(3,5-Dichlorophenoxy)piperidine

HRID 2185480노트

반응식

HRID 2185480 반응식
FC(F)(F)C(O)=O.C(OC([N:15]1[CH2:20][CH2:19][CH:18]([O:21][C:22]2[CH:27]=[C:26]([Cl:28])[CH:25]=[C:24]([Cl:29])[CH:23]=2)[CH2:17][CH2:16]1)=O)(C)(C)C>ClCCl>[Cl:29][C:24]1[CH:23]=[C:22]([CH:27]=[C:26]([Cl:28])[CH:25]=1)[O:21][CH:18]1[CH2:19][CH2:20][NH:15][CH2:16][CH2:17]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 22458487n-Tert-butoxycarbonyl-4-(3,5-dichlorophenoxy)piperidine

생성물 1

HCID 224584124-(3,5-Dichlorophenoxy)piperidine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Trifluoroacetic acid (10 mL) was added to a solution of N-tert-butoxycarbonyl-4-(3,5-dichlorophenoxy)piperidine (A, 815 mg) in dichloromethane (20 mL) at room temperature. After stirring at room temperature for 30 min, the reaction mixture was evaporated in vacuo. The residue was partitioned between chloroform and saturated sodium hydrogen carbonate. The organic layer was dried over anhydrous sodium sulfate and then concentrated in vacuo to give the title compound, which was washed with hexane and used in the next reaction without further purification.

후처리

  1. customthe reaction mixture was evaporated in vacuo
  2. customThe residue was partitioned between chloroform and saturated sodium hydrogen carbonate
  3. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-0e938db6a8f0498b9f01c9ccc8bba9cc
출처 데이터셋
uspto-grants-2002_06
특허 번호
US06399629B1

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