5-Benzyloxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid → 5-benzyloxy-N-(6-isopropylpyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide

HRID 218550

반응식

HRID 218550 반응식
[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[CH2:11][CH2:12][CH2:13][CH:14]2[C:19]([OH:21])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:22][C:23]1[CH:24]=[CH:25][C:26]([CH:29]([CH3:31])[CH3:30])=[N:27][CH:28]=1>>[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[CH2:11][CH2:12][CH2:13][CH:14]2[C:19]([NH:22][C:23]1[CH:28]=[N:27][C:26]([CH:29]([CH3:31])[CH3:30])=[CH:25][CH:24]=1)=[O:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 112083185-Benzyloxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acidHCID 178542886-(Propan-2-yl)pyridin-3-amine

생성물 1

HCID 178542155-benzyloxy-N-(6-isopropylpyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide수율 73.5%

실험 절차

By the reaction and treatment in the same manner as in Preparation Example 11 using 5-benzyloxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid (1.06 g) and 5-amino-2-isopropylpyridine (0.50 g) as starting materials, 5-benzyloxy-N-(6-isopropylpyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (1.08 g) was obtained. melting point: 157.4° C.

후처리

  1. customBy the reaction and treatment in the same manner

출처 및 근거

ORD 기록
ord-5da7bcd1c9c3406d95f08db87ec152a6
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08198454B2

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