Methanol → methyl (2S)-2,3-dihydro-1H-indole-2-carboxylate

반응식

[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C@H:2]1[C:10]([OH:12])=[O:11].[CH3:13]O>S(=O)(=O)(O)O>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C@H:2]1[C:10]([O:12][CH3:13])=[O:11]

참가 물질

실험 절차

Indoline-2(S)-carboxylic acid (10 g, 64 mmol) was refluxed in a mixture of methanol (50 ml) and sulphuric acid (8 ml) for 5 h. The solvent was removed to give the product in the form of an oil.

후처리

customThe solvent was removed
customto give the product in the form of an oil

출처 및 근거

ORD 기록: ord-e67c410ff18343e7a8bb2b621cca852e
출처 데이터셋: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06403561B1

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참가 물질

반응물 2

HCID 887Methanol

HCID 2733920Indoline-2-carboxylic acid, (S)-

생성물 1

HCID 7020378methyl (2S)-2,3-dihydro-1H-indole-2-carboxylate

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

Indoline-2(S)-carboxylic acid (10 g, 64 mmol) was refluxed in a mixture of methanol (50 ml) and sulphuric acid (8 ml) for 5 h. The solvent was removed to give the product in the form of an oil.

후처리

customThe solvent was removed
customto give the product in the form of an oil

출처 및 근거

ORD 기록: ord-e67c410ff18343e7a8bb2b621cca852e
출처 데이터셋: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06403561B1

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불러오는 중…