Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chloro-3-pyridinol → 2-Chloro-3-(1-Boc-2-(R)-azetidinylmethoxy)pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chloro-3-pyridinol | HCID 81136 | — |
| 반응물 | 3-Fluoro-5-hydroxypyridine | HCID 2762906 | — |
| 반응물 | Boc-(S)-hydroxymethylazetidine | HCID 21345256 | — |
| 반응물 | 5-(Benzyloxy)pyridin-3-amine | HCID 22989735 | — |
| 생성물 | 2-Chloro-3-(1-Boc-2-(R)-azetidinylmethoxy)pyridine | HCID 21345165 | — |
반응 단계
The procedures of examples 10c and 10d were used, substituting Boc-(R)-hydroxymethylazetidine for the Boc-(S)-hydroxymethylazetidine used in step 10c, and 2-chloro-3-hydroxypyridine for 3-fluoro-5-hydroxypyridine in step 10d. The title compound was obtained as an oil (535 mg, 93%): 1H NMR (CDCl3, 300 MHz) δ1.40 (s, 9H), 2.40 (m, 2H), 3.90-4.00(m, 2H), 4.16 (m, 1H), 4.55 (m, 2H), 7.20 (m, 1H), 7.35 (m, 1H), 8.00 (m, 1H); MS (CI/NH3) m/z: 299 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06403575B1 |
| 출처 데이터셋 | uspto-grants-2002_06 |
| ORD ID | ord-aa7fcaa1f53b4a2486ba13b43861654d |
| 출처 메모 | uspto-grants-2002_06 |