Oxalyl chloride → 3-Cyano-5,6,7,8-tetrahydronaphthalene-1-carbonyl chloride
반응식
[C:1]([C:3]1[CH:4]=[C:5]([C:13]([OH:15])=O)[C:6]2[CH2:7][CH2:8][CH2:9][CH2:10][C:11]=2[CH:12]=1)#[N:2].C(Cl)(=O)C([Cl:19])=O>C(Cl)Cl.CN(C=O)C>[C:1]([C:3]1[CH:4]=[C:5]([C:13]([Cl:19])=[O:15])[C:6]2[CH2:7][CH2:8][CH2:9][CH2:10][C:11]=2[CH:12]=1)#[N:2]참가 물질
5
실험 절차
To a solution of 3-cyano-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid (0.207 g, 1.03 mmol) in DCM (5 mL) was added oxalyl chloride (0.112 mL, 1.29 mmol) and 1 drop of DMF. The mixture was stirred at room temperature for 2 h., the solvent was removed in vacuo and the 3-cyano-5,6,7,8-tetrahydro-1-naphthalenecarbonyl chloride was used without purification.
후처리
- customthe solvent was removed in vacuo
- customthe 3-cyano-5,6,7,8-tetrahydro-1-naphthalenecarbonyl chloride was used without purification
출처 및 근거
- ORD 기록
- ord-055cebf526db482ba19956c73b9b5f72
- 출처 데이터셋
- uspto-grants-2002_06
- 특허 번호
- US06403601B1
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