Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → HCID 178441542, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Ethyl oxoacetate | HCID 70211 | — |
| 반응물 | 2-n-butyl-4-(2-aminoethyl)-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methylimidazole hydrochloride | HCID 178441647 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | HCID 178441542 | HCID 178441542 | 44.1% |
반응 단계
A mixture of 2-n-butyl-4-(2-aminoethyl)-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methylimidazole hydrochloride (0.278 g), ethyl glyoxylate (0.179 g) and ethanol (5 ml) is refluxed for three days. To the mixture is added chloroform, and the mixture is washed, dried and evaporated to remove the solvent. The residue is purified by silica gel column chromatography (solvent; chloroform/methanol=10:1) to give ethyl 2-n-butyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine-4-carboxylate (0.136 g) as a foam.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05424316 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-742dd5582cf84816bba334ec2f3a2fc0 |
| 출처 메모 | uspto-grants-1995_06 |