Methyl 4-(bromomethyl)-3-chlorobenzoate → Methyl 3-chloro-4-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoate

HRID 2186045노트

반응식

HRID 2186045 반응식
Br[CH2:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][C:4]=1[Cl:13].[C:14]1(=[O:24])[NH:18][C:17](=[O:19])[C:16]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:15]12.[K]>CN(C)C=O>[C:14]1(=[O:24])[N:18]([CH2:2][C:3]2[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][C:4]=2[Cl:13])[C:17](=[O:19])[C:16]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:15]12

참가 물질

4

반응물 2

HCID 22027761Methyl 4-(bromomethyl)-3-chlorobenzoateHCID 24194345Phthalimide potassium salt

생성물 1

HCID 22451715Methyl 3-chloro-4-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
85 °C

실험 절차

A mixture of methyl 4-bromomethyl-3-chlorobenzoate 10 g, 38 mmol) and potassium phthalimide (9.85 g, 53 mmol) in dimethylformamide (65 mL) was stirred and heated to 85° C. for 2 h. The hot mixture was poured into ice water and the resulting solid was filtered, washed sequentially with water, ethanol and a small amount of ether and dried to give the title compound.

후처리

  1. filtrationthe resulting solid was filtered
  2. washwashed sequentially with water, ethanol
  3. dry with materiala small amount of ether and dried

출처 및 근거

ORD 기록
ord-e1b64eb5c6974cd9b8f96fea8b134ce1
출처 데이터셋
uspto-grants-2002_06
특허 번호
US06403578B1

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