Bromine → HCID 178441504, 화합물

HRID 2186097노트

반응식

HRID 2186097 반응식
[C:1]([C:5]1[NH:6][C:7]2[CH:13]=[C:12]([NH2:14])[CH:11]=[CH:10][C:8]=2[N:9]=1)([CH3:4])([CH3:3])[CH3:2].[Br:15]Br>CC(O)=O>[C:1]([C:5]1[NH:6][C:7]2[C:13]([Br:15])=[C:12]([NH2:14])[CH:11]=[CH:10][C:8]=2[N:9]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 2

HCID 24408BromineHCID 21134482-tert-butyl-1H-benzimidazol-5-amine

생성물 1

HCID 178441504HCID 178441504, 화합물수율 67%

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
25 °C

실험 절차

To a solution of 0.53 g (2.8 mmol) of 2-tert-butyl-5-aminobenzimidazole in 50 ml of AcOH was added 0.05 ml (1.0 mmol) of Br2 dropwise and resulting reaction mixture was stirred for 1 h at 25° C. Reaction mixture was concentrated in vacuo and purified on silica gel column chromatography (CHCl3, neat) to yield 0.18 g (0.67 mmol, 67%) of the desired product.

후처리

  1. customresulting
  2. customreaction mixture
  3. customReaction mixture
  4. concentrationwas concentrated in vacuo
  5. custompurified on silica gel column chromatography (CHCl3, neat)

출처 및 근거

ORD 기록
ord-89a9ebdbe3364fadabccff10eac6e423
출처 데이터셋
uspto-grants-2002_06
특허 번호
US06403626B1

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