Sodium Carbonate → HCID 70193430, 화합물

HRID 2186428노트

반응식

HRID 2186428 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:8]=[CH:9][N:10]([CH:12]([CH3:16])[CH2:13][CH:14]=O)[CH:11]=2)[CH:2]=1.[NH:17]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[NH2:18].C(=O)([O-])[O-].[Na+].[Na+]>CC(O)=O.O.CCOC(C)=O>[CH3:23][C:22]([O:21][C:19]([NH:17][NH:18][CH2:14][CH2:13][C@H:12]([N:10]1[CH:11]=[C:7]([C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)[N:8]=[CH:9]1)[CH3:16])=[O:20])([CH3:25])[CH3:24]

참가 물질

7

반응물 3

HCID 10340Sodium CarbonateHCID 70091tert-Butyl carbazateHCID 18759767β-Methyl-4-(3-pyridinyl)-1H-imidazole-1-propanal

생성물 1

HCID 70193430HCID 70193430, 화합물

시약·촉매·용매 3

HCID 176Acetic Acid용매HCID 962Water용매HCID 8857Ethyl Acetate용매

실험 절차

(R/S)-3-(4-pyridin-3-yl-imidazol-1-yl)-butan-1-al (11) (1 mmol) is dissolved in 10 mL HOAc and t-butyl hydrazinecarboxylate (1.1 mmol) is added. After 1 h, NaHB(OAc)3 (5 mmol) is added at 25° C. After 2 h, the reaction is poured into sodium carbonate in water and EtOAc. The water layer is removed, the organics are washed with brine, and dried over sodium sulfate. The solvent is removed in vacuo to leave the product (32).

후처리

  1. waitAfter 2 h
  2. customThe water layer is removed
  3. washthe organics are washed with brine
  4. dry with materialdried over sodium sulfate
  5. customThe solvent is removed in vacuo

출처 및 근거

ORD 기록
ord-ecf2ad3b1cd74d89a09ecf67779636c5
출처 데이터셋
uspto-grants-2002_06
특허 번호
US06403776B1

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