Morpholine → 7-Bromo-4-methoxy-2-(morpholin-4-yl)-benzooxazole

HRID 2186446노트

반응식

[Br:1][C:2]1[C:10]2[O:9][C:8](SC)=[N:7][C:6]=2[C:5]([O:13][CH3:14])=[CH:4][CH:3]=1.[NH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>>[Br:1][C:2]1[C:10]2[O:9][C:8]([N:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)=[N:7][C:6]=2[C:5]([O:13][CH3:14])=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 8083Morpholine

HCID 224566517-Bromo-4-methoxy-2-methylsulfanylbenzooxazole

생성물 1

HCID 224566577-Bromo-4-methoxy-2-(morpholin-4-yl)-benzooxazole

반응 조건

온도: 80 °C

실험 절차

A mixture of 7-bromo-4-methoxy-2-methylsulfanylbenzooxazole (10.0 g) and morpholine (6.6 ml) were heated at 80° C. for 18 hours. Purification by chromatography on silica eluting with 20-100% ethyl acetate in heptane afforded the title compound as an off-white solid (11.6 g).

후처리

customPurification by chromatography on silica eluting with 20-100% ethyl acetate in heptane

출처 및 근거

ORD 기록: ord-dbf4b158d40c4f529ad1063a144de0d7
출처 데이터셋: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06403791B1

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