Sulfuric Acid → 3-Hydroxy-2-naphthoic acid

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[OH:1][C:2]1[C:11]([C:12]([O-:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=1.[Na+].S(=O)(=O)(O)O>>[OH:1][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=1

참가 물질

반응물 2

HCID 1118Sulfuric Acid

HCID 23672297Sodium 3-hydroxy-2-naphthoate

생성물 1

HCID 71043-Hydroxy-2-naphthoic acid수율 90%

반응 조건

온도: 160 °C

실험 절차

To a 1 L autoclave, 800 g of aqueous solution containing 100 g of sodium 2-hydroxynaphthalene-3-carboxylate prepared by means of the Kolbe-Schmitt method was fed and heated to 160° C. An aqueous sulfuric acid solution (72%) was added dropwise to the solution over 50 minutes to adjust the pH of the mixture to 3.5. Then, the mixture was cooled to 80° C. at the rate of 0.4° C./min. At the same temperature, the mixture was filtrated to give 80.6 g of crystalline 2-hydroxynaphthalene-3-carboxylic acid.

후처리

customprepared by means of the Kolbe-Schmitt method
temperatureThen, the mixture was cooled to 80° C. at the rate of 0.4° C./min
filtrationAt the same temperature, the mixture was filtrated

출처 및 근거

ORD 기록: ord-40d5e710604c424099929d9650a38174
출처 데이터셋: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06403827B1

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