Potassium Hydroxide → 2-Methoxy-3-methylbenzoic acid

HRID 2186637

반응식

HRID 2186637 반응식
[CH3:1][O:2][C:3]1[C:12]([CH3:13])=[CH:11][CH:10]=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].[OH-].[K+]>CO.O>[CH3:1][O:2][C:3]1[C:12]([CH3:13])=[CH:11][CH:10]=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 13229229Methyl 2-methoxy-3-methylbenzoate

생성물 1

HCID 9523962-Methoxy-3-methylbenzoic acid수율 95%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

To a solution of 2 (1.19 mol) in a mixture of methanol (2 L) and water (0.5 L), potassium hydroxide pellets (100 gram, 1.5 mol) were added under cooling. The mixture was refluxed overnight and evaporated to dryness. The residue was dissolved in water (0.5 L) and acidified with HCl 6N. The product precipitated and 189 g of product was collected as white crystals. Yield 95%. 1H NMR (500 MHz, CDCl3, 25° C.) δ: 2.234 (s, 3H, CH3), 3.717 (s, 3H, OCH3), 7.062 (t, J=7.5, 1H, ArH), 7.365 (d, J=7.5, 1H, ArH), 7.496 (d, J=7.5, 1H, ArH).

후처리

  1. additionwere added
  2. temperatureunder cooling
  3. temperatureThe mixture was refluxed overnight
  4. customevaporated to dryness
  5. dissolutionThe residue was dissolved in water (0.5 L)
  6. customThe product precipitated
  7. custom189 g of product was collected as white crystals

출처 및 근거

ORD 기록
ord-dbaf181f786043bd93d9666b8a8a3bf8
출처 데이터셋
uspto-grants-2002_06
특허 번호
US06406297B1

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