2-Nitrotoluene → Benzaldehyde

HRID 2186650

반응식

HRID 2186650 반응식
[Br-].C(N([P+](N(CC)CC)(N(CC)CC)N(CC)CC)CC)C.[F-:23].[K+].[N+](C1C=CC=CC=1C)([O-])=O.Cl[C:36]1[CH:43]=[CH:42][C:39]([CH:40]=[O:41])=[CH:38][CH:37]=1>CN1CCCC1=O.C1(C)C(C)=CC=CC=1>[F:23][C:36]1[CH:43]=[CH:42][C:39]([CH:40]=[O:41])=[CH:38][CH:37]=1.[CH:40](=[O:41])[C:39]1[CH:42]=[CH:43][CH:36]=[CH:37][CH:38]=1

참가 물질

8

반응물 4

HCID 69442-NitrotolueneHCID 77264-ChlorobenzaldehydeHCID 522689Potassium FluorideHCID 11036771Tetrakis(diethylamino)phosphonium bromide

생성물 2

HCID 240BenzaldehydeHCID 680234-Fluorobenzaldehyde

시약·촉매·용매 2

HCID 7237O-Xylene용매HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

At 60° C., a solution of 12.0 g (0.03 mol) of tetrakis(diethylamino)phosphonium bromide in 12 g of N-methylpyrrolidone (NMP), 174.3 g (3 mol) of potassium fluoride, 4.1 g (0.03 mol) of nitrotoluene and 18 ml of xylene are successively added to 421.7 g (3 mol) of 4-chlorobenzaldehyde (4-CBAL). The reaction mixture is dried by azeotropic distillation of the xylene under reduced pressure. After 24 hours at 1 90° C., the formation of 4-fluorobenzaldehyde (4-FBAL) and of benzaldehyde produced by dehalogenation, and the conversion of the reaction are determined by gas chromatography.

후처리

  1. dry with materialThe reaction mixture is dried by azeotropic distillation of the xylene under reduced pressure

출처 및 근거

ORD 기록
ord-952e4b891acd47d899810b31b7163350
출처 데이터셋
uspto-grants-2002_06
특허 번호
US06407029B1

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