Dichloromethane → Ramipril

HRID 2187112

반응식

HRID 2187112 반응식
C(O)(=O)/C=C\C(O)=O.C([O:16][C:17]([C@H:19]1[N:23]([C:24](=[O:42])[C@@H:25]([NH:27][C@H:28]([C:37]([O:39][CH2:40][CH3:41])=[O:38])[CH2:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH3:26])[C@H:22]2[CH2:43][CH2:44][CH2:45][C@H:21]2[CH2:20]1)=[O:18])C1C=CC=CC=1.ClCCl>C(N(CC)CC)C>[CH3:41][CH2:40][O:39][C:37]([C@@H:28]([NH:27][C@H:25]([C:24]([N:23]1[C@H:19]([C:17]([OH:18])=[O:16])[CH2:20][C@H:21]2[C@@H:22]1[CH2:43][CH2:44][CH2:45]2)=[O:42])[CH3:26])[CH2:29][CH2:30][C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)=[O:38]

참가 물질

4

반응물 2

HCID 6344DichloromethaneHCID 10121882HCID 10121882, 화합물

생성물 1

HCID 5362129Ramipril

시약·촉매·용매 1

HCID 8471Triethylamine용매

반응 조건

온도
2.5 °C

실험 절차

A 1.0 g portion of (2S,3aS,6aS)-1-[(S)-2-[[(S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid benzyl ester maleic acid salt 1 was placed into 100 mL of dichloromethane, and was cooled to 0-5° C. Triethylamine (0.19 g) was added to the mixture. The resulting mixture was washed with water, and the organic phase was evaporated to give an oil. This oil was deprotected using hydrogenolysis, as per examples stated in EP 079022 to give Ramipril as a white solid.

후처리

  1. washThe resulting mixture was washed with water
  2. customthe organic phase was evaporated
  3. customto give an oil

출처 및 근거

ORD 기록
ord-2ba52ce1ab474547a63de27377c6daf5
출처 데이터셋
uspto-grants-2002_06
특허 번호
US06407262B1

연결된 노트

불러오는 중…