Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzyl Bromide → 1-Benzyl-5-chloro-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzyl Bromide | HCID 7498 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 5-Chloroindole | HCID 87110 | — |
| 촉매 | 18-Crown-6 | HCID 28557 | — |
| 생성물 | 1-Benzyl-5-chloro-1H-indole | HCID 18476362 | 60% |
반응 단계
3.85 g (30 mmol) 5-chloroindole was treated with 6.84 g (40 mmol) benzylbromide, 1.97 g (30 mmol) potassium hydroxide (85% powdered in mortar) and 0.25 g (1 mmol) 18-crown-6 as described in Synthesis 1979 p. 618, giving 4.35 g (60%) 5-chloro-1-benzyl-1H-indole, yellow oil, MS (Ei 70 eV) m/Z M+241.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06410562B1 |
| 출처 데이터셋 | uspto-grants-2002_06 |
| ORD ID | ord-c8bb294274f149a486021e2c82c96850 |
| 출처 메모 | uspto-grants-2002_06 |