Thionyl Chloride → HCID 18476333, 화합물

반응식

[F:1][C:2]([F:20])([F:19])[C:3]1[NH:4][C:5]2[C:10]([C:11]=1[C:12](O)=[O:13])=[CH:9][C:8]([C:15]([F:18])([F:17])[F:16])=[CH:7][CH:6]=2.S(Cl)([Cl:23])=O>>[F:1][C:2]([F:20])([F:19])[C:3]1[NH:4][C:5]2[C:10]([C:11]=1[C:12]([Cl:23])=[O:13])=[CH:9][C:8]([C:15]([F:18])([F:17])[F:16])=[CH:7][CH:6]=2

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 17840233HCID 17840233, 화합물

생성물 1

HCID 18476333HCID 18476333, 화합물

반응 조건

온도: 70 °C

실험 절차

A mixture of 500 mg (1.68 mmol) of the indolecarboxylic acid from Step 4 and 20 ml of thionyl chloride was heated for 3 at 70° C. The excess of thionyl chloride was removed under reduced pressure and the remaining crude acid chloride was dissolved in 30 ml of dry dichloromethane. This solution was used in the next step.

후처리

customThe excess of thionyl chloride was removed under reduced pressure
dissolutionthe remaining crude acid chloride was dissolved in 30 ml of dry dichloromethane

출처 및 근거

ORD 기록: ord-4d058dc91015445e8e9229bb609a49e8
출처 데이터셋: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06410562B1

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