Potassium Carbonate → 4-Benzyloxy-3-[2-(t-butoxycarbonylamino)ethoxy]benzonitrile

HRID 2187932노트

반응식

HRID 2187932 반응식
Br[CH2:2][CH2:3][NH:4][C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8].[CH2:12]([O:19][C:20]1[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[CH:22][C:21]=1[OH:28])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH2:12]([O:19][C:20]1[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[CH:22][C:21]=1[O:28][CH2:2][CH2:3][NH:4][C:5]([O:6][C:7]([CH3:10])([CH3:9])[CH3:8])=[O:11])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 4103526tert-Butyl N-(2-bromoethyl)carbamateHCID 154534514-(Benzyloxy)-3-hydroxybenzonitrile

생성물 1

HCID 226451464-Benzyloxy-3-[2-(t-butoxycarbonylamino)ethoxy]benzonitrile

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
100 °C

실험 절차

8.0 g (35.7 mmol) of t-butyl (2-bromoethyl)carbamate was dissolved in 20 ml of DMF. 4.0 g (17.7 mmol) of 4-benzyloxy-3-hydroxybenzonitrile and 7.4 g (41.3 mmol) of potassium carbonate were added to the obtained solution, and they were stirred at 100° C. for 3 hours. After the treatment with ethyl acetate as the extraction solvent in an ordinary manner, the solvent was evaporated, and the obtained residue was purified by the silica gel column chromatography to obtain the title compound.

후처리

  1. customAfter the treatment with ethyl acetate as the extraction solvent in an ordinary manner, the solvent was evaporated
  2. customthe obtained residue was purified by the silica gel column chromatography

출처 및 근거

ORD 기록
ord-b659d094475f4c28ab0c5251511c7406
출처 데이터셋
uspto-grants-2002_06
특허 번호
US06410538B2

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