Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 1-Dimethylsulfamoyl-2-ethylimidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-Ethylimidazole | HCID 66130 | — |
| 반응물 | Dimethylsulphamoyl chloride | HCID 83372 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 1-Dimethylsulfamoyl-2-ethylimidazole | HCID 23293183 | 86.1% |
반응 단계
To a stirred solution of 2-ethylimidazole (100 g) and triethylamine (115 g) in chloroform (800 ml) at 0° C. is added a solution of dimethylsulfamoyl chloride (153 g) in chloroform (200 ml). The mixture is stirred overnight at room temperature. Water (1.5 liter) is added to the reaction mixture after which the organic layer is separated and concentrated. The residue is dissolved in ethyl acetate (1 liter) and washed with water, and then dried over sodium sulfate and concentrated. Distillation gives 1-dimethylsulfamoyl-2-ethylimidazole (182 g) as a colorless liquid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05424316 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-61bc5d6024df4362ad3eac19e9288450 |
| 출처 메모 | uspto-grants-1995_06 |