1-(2-(2,4-Difluorophenyl)-2,3-epoxypropyl)-1H-1,2,4-triazole → 6-(4-Benzyloxybutyl)-3-[2-(2,4-difluorophenyl)-2-hydroxy-3-[1,2,4]triazol-1-ylpropyl]-thieno[2,3-d]pyrimidin-4(3H)-one

HRID 2189014노트

반응식

HRID 2189014 반응식
[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[S:22][C:16]2[N:17]=[CH:18][NH:19][C:20](=[O:21])[C:15]=2[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:23][C:24]1[CH:29]=[C:28]([F:30])[CH:27]=[CH:26][C:25]=1[C:31]1([CH2:34][N:35]2[CH:39]=[N:38][CH:37]=[N:36]2)[CH2:33][O:32]1>>[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[S:22][C:16]2[N:17]=[CH:18][N:19]([CH2:33][C:31]([C:25]3[CH:26]=[CH:27][C:28]([F:30])=[CH:29][C:24]=3[F:23])([OH:32])[CH2:34][N:35]3[CH:39]=[N:38][CH:37]=[N:36]3)[C:20](=[O:21])[C:15]=2[CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 101309211-(2-(2,4-Difluorophenyl)-2,3-epoxypropyl)-1H-1,2,4-triazoleHCID 685126476-(4-benzyloxybutyl)-thieno[2,3-d]pyrimidin-4(3H)-one

생성물 1

HCID 442321016-(4-Benzyloxybutyl)-3-[2-(2,4-difluorophenyl)-2-hydroxy-3-[1,2,4]triazol-1-ylpropyl]-thieno[2,3-d]pyrimidin-4(3H)-one

실험 절차

This compound was prepared by procedure B using 6-(4-benzyloxybutyl)-thieno[2,3-d]pyrimidin-4(3H)-one and 1[[2-(2,4-difluorophenyl)oxiranyl]methyl]-1H-1,2,4-triazole of the Formula (5). 1HNMR (CDCl3, 200 MHz): 1.61-1.86 (m, 4H), 2.84 (t, J=6 Hz, 2H), 3.49 (t, J=6 Hz, 2H), 4.23 (d, J=16 Hz, 1H), 4.49 (s, 2H), 4.53 (d, J=16 Hz, 1H), 4.72 (d, J=16 Hz, 1H), 4.80 (d, J=16 Hz, 1H), 6.22 (s, 1H), 6.72-6.90 (m, 2H), 7.08 (s, 1H), 7.32 (bs, 5H), 7.50-7.62 (m, 1H), 7.84 (s, 1H), 7.92 (s, 1H), 8.10 (s, 1H).

후처리

  1. customThis compound was prepared by procedure B

출처 및 근거

ORD 기록
ord-4e660a53b6854a1890b987b036334eaa
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08324227B2

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