N,N-Dimethyl-1,3-propanediamine → N-[3-(dimethylamino)propyl]-2-nitrobenzenesulfonamide

HRID 2189391노트

반응식

HRID 2189391 반응식
[CH3:1][N:2]([CH3:7])[CH2:3][CH2:4][CH2:5][NH2:6].C(N(CC)CC)C.[N+:15]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[S:24](Cl)(=[O:26])=[O:25])([O-:17])=[O:16]>ClCCl>[CH3:1][N:2]([CH3:7])[CH2:3][CH2:4][CH2:5][NH:6][S:24]([C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[N+:15]([O-:17])=[O:16])(=[O:25])=[O:26]

참가 물질

5

반응물 3

HCID 7993N,N-Dimethyl-1,3-propanediamineHCID 8471TriethylamineHCID 155402-Nitrobenzenesulfonyl chloride

생성물 1

HCID 4125491N-[3-(dimethylamino)propyl]-2-nitrobenzenesulfonamide수율 97.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of N,N-dimethyl-1,3-diaminopropane (0.92 g) and triethylamine (0.95 mL) in dichloromethane (10 mL) was added 2-nitrobenzenesulfonyl chloride (1 g), and the mixture was stirred at room temperature overnight. The reaction mixture was purified by column chromatography on silica gel (eluent: dichloromethane/methanol=10/1) to give the title compound (1.26 g).

후처리

  1. customThe reaction mixture was purified by column chromatography on silica gel (eluent: dichloromethane/methanol=10/1)

출처 및 근거

ORD 기록
ord-e9aa584210a14e65b4e4982cbfd4f622
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08324176B2

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