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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 218963생성일: 2026년 10월 26일

(1R,2R)-2-Aminocyclohexanol → 3-(2-Fluoro-4-iodo-phenylamino)-N-(trans-2-hydroxy-cyclohexyl)-isonicotinamide

https://huagongshe.com/reaction/218963

반응식

참여 물질

역할이름HCID투입량
반응물(1R,2R)-2-AminocyclohexanolHCID 735777—
반응물3-((2-Fluoro-4-iodophenyl)amino)isonicotinic acidHCID 59026791—
생성물3-(2-Fluoro-4-iodo-phenylamino)-N-(trans-2-hydroxy-cyclohexyl)-isonicotinamideHCID 67250624—

반응 단계

3-(2-Fluoro-4-iodo-phenylamino)-N-(trans-2-hydroxy-cyclohexyl)-isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.27 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 0.40 mmol of trans-2-aminocyclohexanol. LC/MS [6.40 (10 min) min; 640 (M+1)]

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08198457B2
출처 데이터셋uspto-grants-2012_06
ORD IDord-21d99e1e26594175a6ed5f104467c5dc
출처 메모uspto-grants-2012_06