Ethyl 4-bromo-5-(3-chloro-4-fluorophenyl)furan-2-carboxylate → Ethyl 5-(3-chloro-4-fluorophenyl)-4-(3-chloro-5-fluorophenyl)furan-2-carboxylate

HRID 2190118노트

반응식

HRID 2190118 반응식
[Cl:1][C:2]1[CH:3]=[C:4](C2C=C(C(OCC)=O)OC=2C2C=CC=C(C#N)C=2)[CH:5]=[C:6]([F:8])[CH:7]=1.Br[C:28]1[CH:29]=[C:30]([C:41]([O:43][CH2:44][CH3:45])=[O:42])[O:31][C:32]=1[C:33]1[CH:38]=[CH:37][C:36]([F:39])=[C:35]([Cl:40])[CH:34]=1>>[Cl:40][C:35]1[CH:34]=[C:33]([C:32]2[O:31][C:30]([C:41]([O:43][CH2:44][CH3:45])=[O:42])=[CH:29][C:28]=2[C:4]2[CH:5]=[C:6]([F:8])[CH:7]=[C:2]([Cl:1])[CH:3]=2)[CH:38]=[CH:37][C:36]=1[F:39]

참가 물질

3

반응물 2

HCID 58064794Ethyl 4-bromo-5-(3-chloro-4-fluorophenyl)furan-2-carboxylateHCID 58064795Ethyl 4-(3-chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylate

생성물 1

HCID 58064790Ethyl 5-(3-chloro-4-fluorophenyl)-4-(3-chloro-5-fluorophenyl)furan-2-carboxylate

실험 절차

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 11A starting with the compound from Example 6A. Purification is carried out using the mobile phase: cyclohexane/ethyl acetate (50:1). 1.07 g (63% of theory) of the title compound with a purity of 81% are obtained.

후처리

  1. customPurification

출처 및 근거

ORD 기록
ord-0d7189686283479f9b9202a8373168ee
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08324268B2

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