Ethyl 4-bromo-5-(4-fluorophenyl)furan-2-carboxylate → Ethyl 4-(3-chlorophenyl)-5-(4-fluorophenyl)furan-2-carboxylate

HRID 2190119노트

반응식

HRID 2190119 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:10]=[C:11]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[O:12][C:13]=2[C:14]2[CH:19]=[CH:18][CH:17]=[C:16](C#N)[CH:15]=2)[CH:5]=[C:6](F)[CH:7]=1.BrC1C=C(C(OCC)=O)OC=1C1C=CC([F:39])=CC=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:10]=[C:11]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[O:12][C:13]=2[C:14]2[CH:19]=[CH:18][C:17]([F:39])=[CH:16][CH:15]=2)[CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 58064766Ethyl 4-bromo-5-(4-fluorophenyl)furan-2-carboxylateHCID 58064795Ethyl 4-(3-chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylate

생성물 1

HCID 58064804Ethyl 4-(3-chlorophenyl)-5-(4-fluorophenyl)furan-2-carboxylate

실험 절차

The synthesis of the title compound takes place in analogy to the synthesis of the compound from Example 11A starting with the compound from Example 7A. Extraction is carried out with dichloromethane and purification with the mobile phase cyclohexane/ethyl acetate (30:1). 4.12 g (41% of theory) of the title compound with a purity of 50% are obtained.

후처리

  1. extractionExtraction
  2. customis carried out with dichloromethane and purification with the mobile phase cyclohexane/ethyl acetate (30:1)

출처 및 근거

ORD 기록
ord-a1905e68fcb840e5a4eebf8afbb13c80
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08324268B2

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