Ethyl 4-bromo-5-(3-chlorophenyl)furan-2-carboxylate → Ethyl 4,5-bis(3-chlorophenyl)furan-2-carboxylate

HRID 2190120노트

반응식

HRID 2190120 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:10]=[C:11]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[O:12][C:13]=2[C:14]2[CH:19]=[CH:18][CH:17]=[C:16](C#N)[CH:15]=2)[CH:5]=[C:6](F)[CH:7]=1.BrC1C=C(C(OCC)=O)OC=1C1C=CC=C([Cl:39])C=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:10]=[C:11]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[O:12][C:13]=2[C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([Cl:39])[CH:15]=2)[CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 58064772Ethyl 4-bromo-5-(3-chlorophenyl)furan-2-carboxylateHCID 58064795Ethyl 4-(3-chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylate

생성물 1

HCID 58064774Ethyl 4,5-bis(3-chlorophenyl)furan-2-carboxylate

실험 절차

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 11A starting with the compound from Example 5A. Extraction is carried out with dichloromethane and purification is by preparative HPLC (RP18 column; eluent: acetonitrile/water gradient). 452 mg (34% of theory) of the title compound are obtained.

후처리

  1. extractionExtraction
  2. customis carried out with dichloromethane and purification

출처 및 근거

ORD 기록
ord-8fded2013afd4d1f818084ddb25f86df
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08324268B2

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