Ethyl 4-bromo-5-(3-chlorophenyl)furan-2-carboxylate → 4-Bromo-5-(3-chlorophenyl)furan-2-carboxylic acid

HRID 2190127노트

반응식

HRID 2190127 반응식
ClC1C=C(C2C=C(C(O)=O)OC=2C2C=CC=C(C#N)C=2)C=C(F)C=1.[Br:25][C:26]1[CH:27]=[C:28]([C:38]([O:40]CC)=[O:39])[O:29][C:30]=1[C:31]1[CH:36]=[CH:35][CH:34]=[C:33]([Cl:37])[CH:32]=1>>[Br:25][C:26]1[CH:27]=[C:28]([C:38]([OH:40])=[O:39])[O:29][C:30]=1[C:31]1[CH:36]=[CH:35][CH:34]=[C:33]([Cl:37])[CH:32]=1

참가 물질

3

반응물 2

HCID 58064772Ethyl 4-bromo-5-(3-chlorophenyl)furan-2-carboxylateHCID 580647984-(3-Chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylic acid

생성물 1

HCID 580647974-Bromo-5-(3-chlorophenyl)furan-2-carboxylic acid

실험 절차

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 20A starting with the compound from Example 5A. Instead of using ethyl acetate, the crude product is extracted with dichloromethane and reacted further without chromatographic purification. 447 mg (98% of theory) of the title compound are obtained.

후처리

  1. extractionInstead of using ethyl acetate, the crude product is extracted with dichloromethane
  2. customreacted further without chromatographic purification

출처 및 근거

ORD 기록
ord-99678ff6324c49449c7f0cf733311f55
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08324268B2

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