4-{[4-Bromo-5-(3-chlorophenyl)furan-2-yl]carbonyl}piperazin-2-one → 4-{[5-(3-Chlorophenyl)-4-(3,5-dimethylphenyl)furan-2-yl]carbonyl}piperazin-2-one
반응식
ClC1C=C(C2C=C(C(N3CCNC(=O)C3)=O)O[C:12]=2[C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([CH3:19])[CH:14]=2)C=CC=1.Br[C:30]1[CH:31]=[C:32]([C:42]([N:44]2[CH2:49][CH2:48][NH:47][C:46](=[O:50])[CH2:45]2)=[O:43])[O:33][C:34]=1[C:35]1[CH:40]=[CH:39][CH:38]=[C:37]([Cl:41])[CH:36]=1>>[Cl:41][C:37]1[CH:36]=[C:35]([C:34]2[O:33][C:32]([C:42]([N:44]3[CH2:49][CH2:48][NH:47][C:46](=[O:50])[CH2:45]3)=[O:43])=[CH:31][C:30]=2[C:17]2[CH:16]=[C:15]([CH3:19])[CH:14]=[C:13]([CH3:12])[CH:18]=2)[CH:40]=[CH:39][CH:38]=1참가 물질
3
실험 절차
The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 18 starting with the compound from Example 27A. 15.0 mg (28% of theory) of the title compound are obtained.
출처 및 근거
- ORD 기록
- ord-a784189c24264ee3a46f809d57a91f2a
- 출처 데이터셋
- uspto-grants-2012_12
- 특허 번호
- US08324268B2
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