Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → 1-((3-Bromofuran-2-yl)methyl)pyrrolidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 반응물 | 3-Bromo-2-furaldehyde | HCID 3367271 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-((3-Bromofuran-2-yl)methyl)pyrrolidine | HCID 71065895 | 65% |
반응 단계
To a solution of 3-bromofuran-2-carbaldehyde (1.5 g, 8.57 mmol) and pyrrolidine (1.42 mL, 17.14 mmol) and CH2Cl2 (30 mL) was added sodium triacetoxyborohydride (3.63 g, 17.14 mmol). The mixture was stirred at room temperature for 5 hours. The resulting mixture was diluted with EtOAc (300 mL) and the organic layer was washed with saturated NaHCO3 and brine then dried (Na2SO4), filtered and concentrated. The residue was purified by column chromatography (silica, 0-10% MeOH in CH2Cl2) to afford the sub-title compound (1.26 g, 65%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08324264B1 |
| 출처 데이터셋 | uspto-grants-2012_12 |
| ORD ID | ord-9a38e33b6d0f452ea1095034341dbbae |
| 출처 메모 | uspto-grants-2012_12 |