Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → 1-((4-Bromofuran-2-yl)methyl)pyrrolidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 반응물 | 4-Bromo-2-furaldehyde | HCID 2757010 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-((4-Bromofuran-2-yl)methyl)pyrrolidine | HCID 71065990 | 61% |
반응 단계
To a solution of 4-bromofuran-2-carbaldehyde (500 mg, 2.85 mmol) and pyrrolidine (0.47 mL, 5.74 mmol) and CH2Cl2 (10 mL) was added sodium triacetoxyborohydride (1.2 g, 5.71 mmol). The mixture was stirred at room temperature overnight. The resulting mixture was diluted with EtOAc (100 mL) and the organic layer was washed with brine then dried (Na2SO4), filtered and concentrated. The residue was purified by column chromatography (silica, 0-5% MeOH in CH2Cl2) to afford the sub-title compound (400 mg, 61%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08324264B1 |
| 출처 데이터셋 | uspto-grants-2012_12 |
| ORD ID | ord-b67cc13bde4c4d6d83486df538e77bc6 |
| 출처 메모 | uspto-grants-2012_12 |