Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → tert-Butyl 4-((4-bromofuran-2-yl)methyl)piperazine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| 반응물 | 4-Bromo-2-furaldehyde | HCID 2757010 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | tert-Butyl 4-((4-bromofuran-2-yl)methyl)piperazine-1-carboxylate | HCID 86699373 | 91.5% |
반응 단계
To a solution of 4-bromofuran-2-carbaldehyde (500 mg, 2.85 mmol) and CH2Cl2 (10 mL) was added tert-butyl piperazine-1-carboxylate (1.06 g, 5.74 mmol) and sodium triacetoxyborohydride (1.2 g, 5.74 mmol). The mixture was stirred at room temperature overnight. The resultant mixture was diluted with EtOAc (100 mL), washed with brine then dried (Na2SO4), filtered and concentrated under reduced pressure. The residue was purified by column chromatography (silica, 0-5% MeOH in CH2Cl2) to afford the sub-title compound (900 mg, 91%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08324264B1 |
| 출처 데이터셋 | uspto-grants-2012_12 |
| ORD ID | ord-9bea93ff56444fe3a645c33854574258 |
| 출처 메모 | uspto-grants-2012_12 |