반응식
[CH3:1][C:2]1[S:6][C:5]([NH:7][C:8]([C:10]2[CH:11]=[CH:12][C:13]([N:16]3[CH2:21][CH2:20][CH:19](C4C=CC=C(C(F)(F)F)C=4)[CH2:18][CH2:17]3)=[N:14][CH:15]=2)=[O:9])=[N:4][C:3]=1[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1.CN(C1CCN(C2C=CC(C(=O)NC3SC(C)=C(C4C=CC=CC=4)N=3)=CN=2)CC1)C(=O)O.ClC1C=CC(C(NC2SC(C)=C(C3C=CC=CC=3)N=2)=O)=CN=1.[C:92]([O:96][C:97](=[O:106])[N:98](C)[CH:99]1CCNCC1)([CH3:95])([CH3:94])[CH3:93]>>[C:92]([O:96][C:97](=[O:106])[N:98]([CH3:99])[CH:19]1[CH2:18][CH2:17][N:16]([C:13]2[CH:12]=[CH:11][C:10]([C:8](=[O:9])[NH:7][C:5]3[S:6][C:2]([CH3:1])=[C:3]([C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)[N:4]=3)=[CH:15][N:14]=2)[CH2:21][CH2:20]1)([CH3:95])([CH3:94])[CH3:93]참가 물질
5
반응물 4
HCID 27568064-N-Boc-4-N-Methyl-aminopiperidine
HCID 33799416-chloro-N-(5-methyl-4-phenyl-1,3-thiazol-2-yl)pyridine-3-carboxamide
HCID 593179814-(3-trifluoromethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-carboxylic acid (5-methyl-4-phenyl-thiazol-2-yl)-amide
HCID 86641503methyl-[5'-(5-methyl-4-phenyl-thiazol-2-ylcarbamoyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl]-carbamic acid생성물 1
실험 절차
With a method similar to that used for the preparation of 4-(3-trifluoromethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-5′-carboxylic acid (5-methyl-4-phenyl-thiazol-2-yl)-amide, methyl-[5′-(5-methyl-4-phenyl-thiazol-2-ylcarbamoyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl]-carbamic acid tent-butyl ester was prepared from 6-chloro-N-(5-methyl-4-phenyl-thiazol-2-yl)-nicotinamide and methyl-piperidin-4-yl-carbamic acid tert-butyl ester. LCMS calcd for C27H33N5O3S (m/e) 507, obsd 508 (M+H).
출처 및 근거
- ORD 기록
- ord-5b78059953234380880b8ddc28c4d762
- 출처 데이터셋
- uspto-grants-2012_12
- 특허 번호
- US08324385B2
연결된 노트
불러오는 중…