1-(5-Cyano-2-pyridinyl)-4-piperidinecarboxylic acid → 4-{(3S,4S)-3-(4-Chloro-phenyl)-4-[(SR)-1-(5-cyano-pyridin-2-ylamino)-ethyl]-piperidine-1-carbonyl}-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-carbonitrile

반응식

ClC1C=CC(C2C(COC3C=CC(Cl)=CN=3)CCN(C(C3C=CC(C4ON=C(C)N=4)=CC=3)=O)C2)=CC=1.[Cl:37][C:38]1[CH:43]=[CH:42][C:41]([C@@H:44]2[C@@H:49]([CH:50]([NH:52][C:53]3[CH:60]=[CH:59][C:56]([C:57]#[N:58])=[CH:55][N:54]=3)[CH3:51])[CH2:48][CH2:47][NH:46][CH2:45]2)=[CH:40][CH:39]=1.[C:61]([C:63]1[CH:64]=[CH:65][C:66]([N:69]2[CH2:74][CH2:73][CH:72]([C:75](O)=[O:76])[CH2:71][CH2:70]2)=[N:67][CH:68]=1)#[N:62]>>[Cl:37][C:38]1[CH:43]=[CH:42][C:41]([C@@H:44]2[C@@H:49]([CH:50]([NH:52][C:53]3[CH:60]=[CH:59][C:56]([C:57]#[N:58])=[CH:55][N:54]=3)[CH3:51])[CH2:48][CH2:47][N:46]([C:75]([CH:72]3[CH2:71][CH2:70][N:69]([C:66]4[CH:65]=[CH:64][C:63]([C:61]#[N:62])=[CH:68][N:67]=4)[CH2:74][CH2:73]3)=[O:76])[CH2:45]2)=[CH:40][CH:39]=1