Diethyl Ether → HCID 86634464, 화합물

HRID 2191168노트

반응식

HRID 2191168 반응식
[CH:1]1([C:4](=[O:9])[CH2:5][CH2:6][CH2:7][OH:8])[CH2:3][CH2:2]1.[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1.C(OCC)C>ClCCl>[CH:1]1([C:4](=[O:9])[CH2:5][CH2:6][CH:7]=[O:8])[CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 3283Diethyl Ether2회HCID 1572618325979-84-4HCID 178418287HCID 178418287, 화합물

생성물 1

HCID 86634464HCID 86634464, 화합물수율 78%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

230 mg (1.79 mmol) of 1-cyclopropyl-4-hydroxy-1-butanone was dissolved in 7 ml of dichloromethane, and 580 mg (2.69 mmol) of pyridinium chlorochromate was added thereto, followed by stirring for 1 hour at room temperature. To the reaction solution was added diethyl ether, the mixture was filtered using Celite, and the filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography (solvent; diethyl ether alone) to give 176 mg of the title compound as a pale yellow oil (yield: 78%).

후처리

  1. filtrationthe mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-602d82a54fd647ea8d9b76e7f662a3dd
출처 데이터셋
uspto-grants-2012_12
특허 번호
USRE043858E1

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